Showing posts with label research. Show all posts
Showing posts with label research. Show all posts

Monday, March 25, 2013

Urge Congress to Fund Cerebral Palsy Research

Cerebral palsy affects more children than muscular dystrophy, multiple sclerosis, cystic fibrosis or childhood leukemia. But CP receives only a fraction of the government research funding these other disorders receive. I wish I knew why. I only know it isn’t right.
Not that these organizations deserve any less research support. I just believe cerebral palsy should warrant more attention. In the U.S., 1 in every 303 eight-year-olds has cerebral palsy. The odds are 1 in every 270 among African-American children. Yet, the cause of 80% of CP is still unknown.
I work with families of children with cerebral palsy on a regular basis. I know what kind of challenges they face, and what it costs to provide children with the kinds of therapies and services they will need the rest of their lives. I present these numbers in courts and around settlement tables. I am well aware that science has not found a way to prevent most cerebral palsy, or to cure it.
Without more research funding, it is unlikely this will occur anytime soon, which is a travesty. Dedicated research funding is practically nonexistent, according to the Academy for Cerebral Palsy and Developmental Medicine. The Centers for Disease Control and Prevention (CDC) has no specific funding for CP, and funds dedicated for CP by the National Institutes of Health (NIH) (only $22million for this year) is not for innovative, curative research, the academy notes.
Today is National Cerebral Palsy Awareness Day. Do your part to urge Congress to dedicate more funding to preventing, curing and developing effective therapies for cerebral palsy. Contact your elected officials. The 800,000 Americans who are living with CP today are counting on you.
For more information about the causes of cerebral palsy, read my blog “Your Child’s Cerebral Palsy: Preventable Mistake or Not?

Wednesday, December 5, 2012

Student’s Work May Help Diagnose Cerebral Palsy Earlier

Do you wish hospitals were able to diagnosis cerebral palsy earlier? Can you imagine being able to start treatment within days rather than months or years? A student at Virginia Tech is working on being able to do just that.

http://www.cpfamilynetwork.org/in-the-news/students-work-may-help-diagnose-cerebral-palsy-earlier

Wednesday, September 12, 2012

Cerebral Palsy: Developmental Milestones Birth to 12 Months

Cerebral Palsy: Developmental Milestones Birth to 12 Months

By Lee Vander LoopCP Family Network Editor
Many children with cerebral palsy are diagnosed shortly after birth. Others, however, may go months or even years with no diagnosis. Without a diagnosis, valuable early therapies and treatments are delayed.
How is a parent struggling with the question “is my child developing normally?” supposed to tell? If you are concerned, you should not hesitate to talk to your doctor. Trust your hunches. According to research, parental concerns detect 70% – 80% of all disabilities in children. So if your gut is telling you something is not right, chances are, it’s not.
Meanwhile, there are guidelines known as “developmental milestones” to help parents determine whether or not their child is keeping up with his or her peers. These milestones are a set of functional skills or age-specific tasks that most children can do at a certain age range. For children who have suffered a brain injury at birth, however, these guidelines often don’t apply. Depending on the severity and location of the brain injury, some children experiencing developmental delays may be able to achieve milestones only through a variety of therapy and interventions. Others with severe brain injuries may never achieve some developmental milestones.

Signs of Cerebral Palsy in Infants Up to 12 Months

The signs of cerebral palsy vary greatly because there are many different types and levels of disability, but an early indication is a delay in controlling movement of the head or arms and legs. This list of cerebral palsy symptoms, divided by age range, is not comprehensive but serves as a good starting point to determine if your child may have developmental delays. If you see any of these signs, call your child’s doctor or nurse.
  • 2 months and older:
    • Have difficulty controlling his head when picked up
    • Have stiff or shaky arms or legs
    • Have stiff legs that cross or “scissor” when picked up
    • Have oral motor difficulties and problems sucking and feeding
  • 6 months and older:
    • Continue to exhibit poor head control when picked up
    • May reach with only one hand while keeping the other in a fist
    • Have problems eating and drinking
    • May not roll over without assistance
    • May not be able to push up with their hands when laying on their stomach
  • 10 months and older:
    • Crawl by pushing off with one hand and leg while dragging the opposite hand and leg
    • Not be able to sit by himself or herself
  • 12 months and older:
    • Not yet crawl or attempt to pull themselves up
    • Not be able to stand with support

Basic Developmental Skills

Cerebral palsy is caused by a problem in the brain that affects a child’s ability to control his or her muscles. Problems in different parts of the brain cause problems in different parts of the body. There are many possible causes of problems, such as genetic conditions, problems with the blood supply to the brain before birth, infections, bleeding in the brain, lack of oxygen, severe jaundice, and head injury. A child who lacks basic motor skills will have difficulty reaching subsequent milestones without help.
The Interdisciplinary Council on Developmental and Learning Disorders Outlines the six basic developmental skills which lay the foundation for all learning and development. Although all children develop at their own rate, growth can be defined in the following areas:
  • Gross Motor – Gross motor enables your baby to achieve major milestones such as head control, sitting, crawling, maybe even starting to walk. Children exhibiting a delay in gross motor skills need to be evaluated as early as possible so they can start getting physical therapy to help them strengthen their muscles.
  • Fine Motor – These skills allow a child to hold a spoon, or pick up a piece of cereal between thumb and finger. Children exhibiting delays in these skills will have difficulty holding a spoon, manipulating small objects or grasping items between their thumb and fingers.
  • Sensory – Sensory skills include seeing, hearing, tasting, touching and smelling.
    A child with a brain injury may have trouble processing information from these senses, a condition known as Sensory Processing Disorder. Normally diagnosed by developmental pediatricians, pediatric neurologists and child psychologists, children experiencing difficulties with sensory processing may exhibit either a “hyper” (over) or “hypo” (under) sensitivity to stimulation of the senses.
  • An infant with hypersensitivity may:
    • Dislike being touched or dressed
    • Seem intolerant of normal lighting in a room
    • Startle easily at small sounds
    An infant with hyposensitivity, may:
    • Seem restless and seek stimulation
    • Not startle or respond to loud noises
  • Language – A child with cerebral palsy may lack the muscle strength in the mouth and tongue to control sounds or may have trouble hearing or processing sound, all of which will delay language. An infant developing normally from birth to 5 months will react to loud sounds, turn her head toward a sound source, watch your face when you speak, make pleasure and displeasure sounds (laugh, giggle, cry, or fuss), and make noise when talked to. Other milestones are listed by the National Institute on Deafness and other Communication Disorders.
  • Social and Emotional– Social and emotional milestones are often harder to pinpoint than signs of physical development. A child from birth to 12 months who has trouble processing sensory input or who has poor control of movement because of a brain injury may be delayed in:
    • Crying to express distress or to attract attention
    • Fixating on faces
    • Smiling purposefully at certain people (mom, for example)
    • Cooing or laughing to attract attention
    • Playing “peek-a-book” or other game
    • Responding to their own names
    • Developing stranger anxiety
    A full list of both social and emotional milestones is listed here.

An Important Note about Developmental Milestones

Developmental milestones are only guidelines. No two babies are alike and no two develop the same, though most reach certain milestones at similar ages. Every child develops at their own rate. If your child was born prematurely, you will need to look at the guidelines a little differently. Also, all human development depends on environmental stimulation. A child deprived of a loving, nurturing and stimulating environment will experience developmental delays.
Your baby’s physician will evaluate your child’s development at each well-baby visit. Don’t be surprised if the pediatrician tells you not to worry, to be patient, to give your child more time to develop. Often, that’s what parents hear, especially in the early stages of investigating their child’s apparent delays. And it’s often true. Children develop at different rates; the pediatrician is well aware that many children show sudden bursts in development rather than slow, steady growth.
On the other hand, your pediatrician may recommend that a developmental screening be conducted. Its purpose is to see if your child is experiencing a developmental delay. The screening is a quick, general measure of your child’s skills and development. It’s not detailed enough to make a diagnosis, but it will show whether a child should be referred for a more in-depth developmental evaluation.

Resources

You can find a wonderful interactive Milestone Checklist at the CDC, provided by the National Center on Birth Defects and Developmental Disabilities. It details specific developmental accomplishments and allows sharing of forms with other caregivers for their input. http://www.cdc.gov/ncbddd/actearly/milestones/index.html
The American Academy of Pediatrics offers a Parenting website, healthychildren.org: Ages & Stages:
http://www.healthychildren.org/English/ages-stages/baby/pages/Developmental-Milestones-1-Month.aspx
National Library of Medicine, National Institute of Health, Medline Plus, Infant and Newborn development
http://www.nlm.nih.gov/medlineplus/infantandnewborndevelopment.html
March of Dimes, Your Growing Baby
http://www.marchofdimes.com/baby/growing_indepth.html
Center for Disease Control and Prevention, CDC, Child Development
http://www.cdc.gov/ncbddd/child/

Tuesday, August 21, 2012

Treatment has Potential to Reverse Cerebral Palsy

Treatment has Potential to Reverse Cerebral Palsy

A child’s symptoms can start with a weak or shrill cry, which seems normal enough. But then other problems appear, such as not being able to swallow or suck properly and having an overly floppy or stiff body.

These are early signs of a group of disorders called cerebral palsy, which is the No. 1 cause of motor disability in American children and affects more than 11,000 kids every year.

Doctors treat the lifelong symptoms with physical therapy and drugs, but are unable to reverse the brain damage, which happens in the womb for most cerebral palsy children.

Now, a study using a nanoparticle has successfully repaired damaged brains in rabbits with cerebral palsy. A research team engineered a particle small enough to deliver anti-inflammatory drugs to overactive neurons in the brain that are killing healthy cells.

Children with cerebral palsy have varying types of brain damage because of genetic mutations, maternal infections that affect fetal brain development, lack of oxygen to the fetus or baby or traumatic brain injury.

In many of these cases, two types of immune cells in the brain become activated — microglia and astrocytes. They protect the brain during infection and inflammation but damage the brain when they go into overdrive, destroying healthy cells.

Controlling neuronal inflammation presents a challenge because most medications can’t get past the blood-brain barrier.

R. Kannan led a group from Johns Hopkins University and Wayne State University that found a solution using a nanoparticle called a dendrimer, which is 2,000 times smaller than a red blood cell.

Kannan’s team affixed a powerful antioxidant with anti-inflammatory properties onto the snowflake-shaped particle.

When intravenously injected into newborn rabbits with an induced form of cerebral palsy, the drug-laced dendrimers made their way to the brain and were immediately swallowed by the overactive immune cells.

Within five days of treatment, the rabbits showed significant improvement, exhibiting motor skills similar to healthy rabbits. By comparison, rabbits treated with just the antioxidant, unattached to a dendrimer, showed minimal improvement even though they were given 10 times the amount.

An autopsy revealed the brains of rabbits treated with dendrimers had less scarring, less brain cell death and reduced inflammation.

They also had better preservation of myelin, a protective cover around nerves, which normally is stripped by cerebral palsy and other neurological diseases. This suggests the new treatment has the potential to reverse the disease.

Before human trials can begin, researchers must determine if the nanoparticle in this study is safe for humans, particularly children whose brains are developing.

There’s also the question of how long doctors have before cerebral palsy is irreversible in children. In most cases, cerebral palsy is diagnosed by the age of 2, but if newborns can be diagnosed and treated immediately, Kannan’s therapy might be invaluable to those young lives.

The study’s scientists already anticipate pairing the treatment with stem cell therapy to regenerate damaged nerve tissue in the brain.

Not only would this help newborns with cerebral palsy, but could also help people with other neurodegenerative diseases such as Alzheimer’s and multiple sclerosis.

Professors Norbert Herzog and David Niesel are biomedical scientists at the University of Texas Medical Branch. Learn more at medicaldiscoverynews.com.